Instructor Notes

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Introduction to the Data Set


Input File Format


Calculating Genotype Probabilities


Instructor Note

We need the following block for the site to build on Github. The students do not need to see or run the next block.



Performing a genome scan


Calculating A Kinship Matrix


Performing a genome scan with a linear mixed model


Performing a genome scan with binary traits


Performing a permutation test


Instructor Note

We need the following block for the site to build on Github. The students do not need to see or run the next block.



Instructor Note

Replace number of permutations (1000) with 100 for expediency. 1000 permutations takes about 2 minutes.



Finding QTL peaks


Instructor Note

We need the following block for the site to build on Github. The students do not need to see or run the next block.



Estimating QTL effects


Integrating Gene Expression Data


QTL Mapping in Diversity Outbred Mice


Instructor Note

The code below is needed to load in the data objects to build the lesson on Github. The *.Rdata file is over 200 Mb and Github has a file size limit of 100 Mb. The students should NOT run the next block.



Instructor Note

This is the only block that the students need to run.



Instructor Note

Remember, you just need to show the basic plot. Just type out the ggplot, geom, log scale, and facet wrap lines in class.



Instructor Note

This code is intended to throw an error. It is used to illustrate the point that you have to align the markers between probs and map.



Instructor Note

Note that you have to add the “genes”, “colors”, and “top_panel_prop” arguments.



Instructor Note

Note that you have to change the “top_panel_prop” argument to “panel_prop” and add the “drop_hilit”, “col_hilit”, and “sdp_panel” arguments.